In which of the following grades does a tumour possess cells that are moderately differentiated?

Appeared in: RRB Nsg. Superintendent - 29 April 2025 (Shift-3rd)

Explanation

Tumor grading is a system that classifies cancers based on the degree of cellular differentiation and the rate of growth.
Grade II tumors are, by definition, composed of cells that are moderately differentiated.
This means the cells have some abnormal features but still retain some resemblance to the normal tissue of origin.
They are more aggressive than Grade I tumors but less aggressive than Grade III and IV tumors.

Option A: Grade IV tumors are undifferentiated or anaplastic, meaning the cells are highly abnormal and bear no resemblance to normal cells.
Option B: Grade I tumors are well-differentiated, meaning the cells look very similar to normal cells and tend to be slow-growing.
Option D: Grade III tumors are poorly differentiated. The cells are very abnormal and have lost most of the features of the original tissue.

Visual 1: Infographic - A diagram showing microscopic views of cells from Grade I to Grade IV, illustrating the progressive loss of differentiation from normal-looking cells (Grade I) to highly abnormal, chaotic cells (Grade IV).

Clinical Relevance

Nursing practice connection: This is primarily an exam-oriented knowledge point with limited direct bedside application, so retain Tumor Grading and Cellular Differentiation as background academic context rather than a clinical decision trigger.
Tumor grade is a critical component of the pathology report and is a key prognostic factor. A higher grade generally corresponds to a poorer prognosis.
Nurses play a vital role in helping patients understand their diagnosis, including the meaning of tumor grade and its implications for their treatment plan and prognosis.
The grade of a tumor helps the oncology team decide on the most appropriate treatment. Higher-grade tumors often require more aggressive treatment, such as chemotherapy or radiation, in addition to surgery.

How to Approach the Question

First, identify the key terms in the question: 'grade' and 'moderately differentiated'.
This is a factual recall question that tests your knowledge of the cancer grading system.
Recall the four main grades of tumors and their corresponding levels of cellular differentiation.
The standard system is: Grade I (Well-differentiated), Grade II (Moderately differentiated), Grade III (Poorly differentiated), and Grade IV (Undifferentiated).
Match the term 'moderately differentiated' to its corresponding grade, which is Grade II.

Concept Tested & Keywords

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Practise the full RRB Nsg. Superintendent - 29 April 2025 (Shift-3rd)

Attempt every question from this paper in a timed mock, then review the full solution for each one.