UPPSC 2022
Pharmacology
Easy
Chlorpromazine drugs was introduced in
Appeared in: UPPSC 2022
Explanation
- Chlorpromazine was introduced into clinical psychiatric practice in 1952 by French psychiatrists Jean Delay and Pierre Deniker.
- This event is considered the beginning of the modern era of psychopharmacology, as it was the first effective drug treatment for psychosis.
- While the drug was synthesized in 1950, its clinical application and the report of its effectiveness occurred in 1952.
- Its success led to a significant reduction in the number of patients in psychiatric hospitals and a shift towards community-based care.
Why Other Options Were Wrong
- Option A: This date is incorrect. Chlorpromazine was synthesized in 1950, so it could not have been introduced in 1942.
- Option C: This date is incorrect. By 1962, Chlorpromazine was already well-established as a primary treatment for psychosis for a decade.
- Option D: This date is incorrect. By 1972, Chlorpromazine had been in use for twenty years, and research was focused on understanding its long-term side effects and developing newer agents.
Related Visual
Clinical Relevance
- Nursing practice connection: This is primarily an exam-oriented knowledge point with limited direct bedside application, so retain History of Psychopharmacology: Introduction of Chlorpromazine as background academic context rather than a clinical decision trigger.
- Understanding the history of psychopharmacology helps nurses appreciate the evolution of mental health care from custodial institutionalization to active therapeutic management.
- As a first-generation (typical) antipsychotic, Chlorpromazine carries a high risk of causing Extrapyramidal Symptoms (EPS) like tremors, rigidity, and tardive dyskinesia. Nurses must be vigilant in assessing for and managing these side effects.
- Patient education is critical. Nurses should teach patients and families to recognize early signs of EPS and the importance of not stopping the medication abruptly.
How to Approach the Question
- Identify the core of the question: It asks for a specific historical date related to a landmark drug in psychiatry.
- Recognize this as a factual recall question that relies on knowledge of medical history.
- Access your knowledge base on the history of psychopharmacology. Recall that the major breakthrough in treating psychosis occurred in the post-World War II era.
- Think about the timeline. Chlorpromazine was the first major antipsychotic, so an earlier date in the mid-20th century is more likely.
- Evaluate the options: 1942 is too early (pre-synthesis). 1962 and 1972 are too late, as the drug would have already been in widespread use. 1952 fits the timeline for the beginning of the psychopharmacological revolution.
- Select 1952 as the correct year for the clinical introduction of Chlorpromazine.
Concept Tested & Keywords
- Concept Tested: History of Psychopharmacology: Introduction of Chlorpromazine
- Stem keywords: Chlorpromazine, introduced
- Lead-in keywords: BEST, MOST RELEVANT CLUE
Question ID
QiECY-dNjG79rrVm38y6_o
Reference Book
E6 Robert Boland, Marcia L. Verduin - Kaplan and Sadock's Comprehensive Text of Psychiatry-Wolters Kluwer Health (2024) (pp 1-16525 of 16525) pp. 9928-9930, 15177-15179, 5064-5066
Practise the full UPPSC 2022
Attempt every question from this paper in a timed mock, then review the full solution for each one.
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