The patients of following blood group have highest tendency of gastric carcinoma

Appeared in: RUHS, Jaipur, M.Sc Nursing Entrance Exam-2023

Explanation

Epidemiological studies have established a significant association between having blood group A and an increased risk of developing gastric carcinoma.
The underlying mechanism is not fully understood but is hypothesized to involve differences in host immune response, particularly to chronic inflammation caused by pathogens like Helicobacter pylori.
Individuals with blood group A may have altered cell-surface glycoproteins that facilitate bacterial adherence or influence the inflammatory cascade, contributing to carcinogenesis.

Option B: Blood group O is not associated with the highest risk of gastric cancer.
Option C: There is no strong evidence to suggest that individuals with AB blood group have the highest tendency for gastric carcinoma compared to blood group A.
Option D: Similar to the AB group, blood group B is not associated with the highest risk of developing gastric carcinoma.

Clinical Relevance

Nursing practice connection: Knowing Association between ABO blood groups and susceptibility to specific diseases helps nurses interpret findings accurately and avoid errors in routine assessment, medication administration, and patient teaching.
Knowing a patient's blood type can be a small part of a comprehensive risk assessment for certain cancers and gastrointestinal diseases.
Nurses should focus on educating patients about modifiable risk factors for gastric cancer, such as diet, smoking, alcohol consumption, and managing H. pylori infections, regardless of blood type.
This knowledge reinforces the importance of personalized medicine, where genetic factors like blood type can provide clues to an individual's disease susceptibility.

How to Approach the Question

This is a factual recall question that tests your knowledge of medical associations.
First, identify the key terms in the question: 'blood group' and 'gastric carcinoma'.
Recall the known epidemiological links between the ABO blood group system and various diseases.
Specifically, remember the association between Blood Group A and gastric cancer, and Blood Group O and peptic ulcers.
Evaluate the options based on this recalled knowledge. Select the option that correctly links the blood group to the specified disease.

Concept Tested & Keywords

Concept Tested: Association between ABO blood groups and susceptibility to specific diseases.
Stem keywords: blood group, highest tendency, gastric carcinoma
Lead-in keywords: highest

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E6 Parks TextBook of Preventive & Social Medicine part 2 — Subpart B (pp 233-449 of 464) p. 141-143

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