Inhibin is secreted by:

Appeared in: AIIMS Nagpur NO- 2020

Explanation

Inhibin is a glycoprotein hormone involved in the negative feedback control of follicle-stimulating hormone (FSH) secretion from the pituitary gland.
In females, inhibin is produced by the granulosa cells of the ovarian follicles.
After ovulation, the follicle transforms into the corpus luteum, which continues to secrete inhibin, along with progesterone and estrogen, during the luteal phase of the menstrual cycle.
This secretion of inhibin from the corpus luteum helps to suppress FSH levels, preventing the development of new follicles during the second half of the cycle.

Option B: The stroma is the connective tissue framework of the ovary. While it contains hormone-producing theca cells, the stroma itself is not the primary source of inhibin.
Option C: Leydig cells are found in the testes of males and their primary function is to produce testosterone.
Option D: The surface epithelium is the outermost layer of cells covering the ovary. It is not involved in the production of reproductive hormones like inhibin.

Clinical Relevance

Nursing practice connection: This is primarily an exam-oriented knowledge point with limited direct bedside application, so retain Endocrine function of the gonads, specifically the source of inhibin secretion as background academic context rather than a clinical decision trigger.
Measuring inhibin levels can be clinically useful. Inhibin B is a marker for Sertoli cell function in males, while in females, inhibin levels are used to assess ovarian reserve and can be elevated in certain ovarian tumors (e.g., granulosa cell tumors).
A nurse may be involved in patient education regarding blood tests for hormone levels, including inhibin, when assessing fertility issues or monitoring for certain cancers.
What if the patient was male? In males, inhibin is secreted by the Sertoli cells in the seminiferous tubules of the testes, where it also acts to inhibit FSH secretion and regulate spermatogenesis.

How to Approach the Question

First, identify the key term in the question: 'Inhibin'.
Recall the function and sources of inhibin. Remember it's a reproductive hormone involved in FSH regulation.
Consider the sources in both females (granulosa cells/corpus luteum) and males (Sertoli cells).
Evaluate each option: 'Corpus luteum' is a known source in females.
Eliminate the other options by recalling their primary functions: Stroma (connective tissue), Leydig cells (testosterone in males), and Surface epithelium (covering).
Confirm that Corpus luteum is the only correct source of inhibin listed among the choices.

Concept Tested & Keywords

Concept Tested: Endocrine function of the gonads, specifically the source of inhibin secretion.
Stem keywords: Inhibin, secreted by
Lead-in keywords: BEST, MOST RELEVANT CLUE

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E6 Physiology Guyton 4SAE Part 3 p. 36-38

E6 Nelson Textbook of Pediatrics(2024) — Volume 2 pp. 1164-1166, 1292-1294

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