Punjab CHO - 2021
Pathology & Genetics
Easy
In which of the following diseases are Negri Bodies observed?
Appeared in: Punjab CHO - 2021
Explanation
- Negri bodies are the classic, pathognomonic finding for Rabies infection.
- These are eosinophilic (pink-staining), sharply defined inclusion bodies found within the cytoplasm of infected neurons.
- They are most frequently found in the pyramidal cells of the hippocampus and the Purkinje cells of the cerebellum.
- Their presence confirms a post-mortem diagnosis of rabies, although they are not found in all cases.
Why Other Options Were Wrong
- Option A: Brucellosis, caused by Brucella species, is characterized by non-caseating granulomas in the reticuloendothelial system (liver, spleen, bone marrow), not Negri bodies.
- Option B: Anthrax, caused by Bacillus anthracis, is identified by the presence of large, Gram-positive, spore-forming rods, often described as having a "bamboo stick" appearance in chains. It does not produce viral inclusion bodies.
- Option D: Tuberculosis, caused by Mycobacterium tuberculosis, is characterized by the formation of caseating granulomas (tubercles) containing Langhans giant cells and acid-fast bacilli. Negri bodies are not associated with this disease.
Related Visual
Clinical Relevance
- Nursing practice connection: This is primarily an exam-oriented knowledge point with limited direct bedside application, so retain Pathognomonic histological findings in infectious diseases as background academic context rather than a clinical decision trigger.
- Identifying Negri bodies is a definitive post-mortem method to confirm rabies, which is crucial for public health investigations to trace the source of infection and manage other potentially exposed individuals.
- For nurses, understanding the severity and invariably fatal outcome of clinical rabies underscores the absolute importance of immediate and correct post-exposure prophylaxis (PEP) for any patient with a potential exposure.
- What if? If a patient presents with neurological symptoms like hydrophobia and agitation after a bat exposure, but a brain biopsy is negative for Negri bodies, rabies cannot be ruled out. Diagnosis would then rely on other tests like RT-PCR on saliva or CSF, as Negri bodies are not present in 100% of cases.
How to Approach the Question
- This is a factual recall question that tests your knowledge of classic pathological findings.
- First, identify the key term in the question: 'Negri Bodies'.
- Next, access your memory or knowledge base to recall the disease specifically associated with this term.
- Evaluate the given options: Brucellosis, Anthrax, Rabies, and Tuberculosis.
- Match the key term 'Negri Bodies' to the correct disease. Negri bodies are pathognomonic for Rabies.
- Confirm your choice by mentally ruling out the other options, recalling their distinct pathological features (e.g., granulomas for TB, 'bamboo stick' bacteria for Anthrax).
Concept Tested & Keywords
- Concept Tested: Pathognomonic histological findings in infectious diseases.
- Stem keywords: Negri Bodies, disease
- Lead-in keywords: observed in
- Negative lead-in flag: false
Question ID
Q3SM27jnNqSXsukrkEHwky
Reference Book
E6 Robert Boland, Marcia L. Verduin - Kaplan and Sadock's Comprehensive Text of Psychiatry-Wolters Kluwer Health (2024) (pp 1-16525 of 16525) p. 2029-2031
Practise the full Punjab CHO - 2021
Attempt every question from this paper in a timed mock, then review the full solution for each one.
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