Which of the following is mRNA vaccine?

Appeared in: UPPSC 2022

Explanation

The Pfizer-BioNTech vaccine is a type of messenger RNA (mRNA) vaccine.
mRNA vaccines work by providing the body's cells with genetic instructions to create a harmless piece of the virus, specifically the spike protein.
This process allows the immune system to develop antibodies and a memory response against the spike protein.
If the person is later exposed to the actual virus, their immune system can quickly recognize and fight it off, preventing severe illness.

Option A: Covishield is not an mRNA vaccine. It is a viral vector vaccine.
Option B: Covaxin is not an mRNA vaccine. It is an inactivated virus vaccine.
Option D: Novavax (marketed as Covovax in India) is not an mRNA vaccine. It is a protein subunit vaccine.

Clinical Relevance

Nursing practice connection: This is primarily an exam-oriented knowledge point with limited direct bedside application, so retain Classification of COVID-19 Vaccines as background academic context rather than a clinical decision trigger.
Nurses play a crucial role in educating patients about different vaccine types, helping them make informed decisions and addressing concerns about vaccine safety and efficacy.
Understanding the vaccine platform (e.g., mRNA, viral vector) is important for recognizing and managing potential side effects and adverse reactions, as some may be specific to the technology used.
Knowledge of vaccine contraindications is essential for patient safety. For example, a known allergy to a component like polyethylene glycol (PEG) is a contraindication for mRNA vaccines (Pfizer, Moderna).

How to Approach the Question

First, identify the key term in the question, which is 'mRNA vaccine'.
This is a factual recall question that requires knowledge of the different types of COVID-19 vaccines.
Systematically review each option and classify it based on its vaccine technology.
Recall or determine that Covishield is a viral vector vaccine, Covaxin is an inactivated vaccine, and Novavax is a protein subunit vaccine.
Identify Pfizer as the vaccine that uses mRNA technology.
Select the option that correctly matches the classification asked for in the question.

Concept Tested & Keywords

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E6 Textbook of Biochemistry for medical StudentsDM Vasudevan Part 2 — Subpart B (pp 240-463 of 478) p. 170-172

E6 Pharmacology KD Tripathi Essentials 9e Part 3 p. 290-292

E6 Medicine Harrison 22e Part 1 p. 1038-1040

Practise the full UPPSC 2022

Attempt every question from this paper in a timed mock, then review the full solution for each one.