DSSSB Public Health Nurse - 2015
Pharmacology
Easy
Which of the following is not a live vaccine?
Appeared in: DSSSB Public Health Nurse - 2015
Explanation
- The HIB (Haemophilus influenzae type b) vaccine is an inactivated polysaccharide conjugate vaccine.
- It is created using only a part of the bacterium (the polysaccharide capsule), not the whole, live organism.
- Because it contains no live components, it cannot replicate or cause disease, classifying it as a non-live vaccine.
Why Other Options Were Wrong
- Option A: The typhoid vaccine can be a live vaccine. The oral Ty21a formulation is a live attenuated vaccine.
- Option C: OPV (Oral Polio Vaccine) is a live attenuated viral vaccine. It contains a weakened form of the poliovirus.
- Option D: BCG (Bacillus Calmette-Guérin) is a live attenuated bacterial vaccine used for protection against tuberculosis.
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Clinical Relevance
- Nursing practice connection: This is primarily an exam-oriented knowledge point with limited direct bedside application, so retain Classification of vaccines (Live vs. Inactivated) as background academic context rather than a clinical decision trigger.
- Understanding the difference between live and inactivated vaccines is critical for safe nursing practice, especially when caring for immunocompromised patients (e.g., those with HIV, undergoing chemotherapy, or on long-term steroids), as they are generally contraindicated from receiving live vaccines.
- Nurses play a key role in educating patients and parents about the immunization schedule and the types of vaccines being administered, including potential side effects and contraindications.
- What if? If a child requiring a HIB vaccine is also severely immunocompromised, the nurse can confidently administer it because it is an inactivated vaccine and poses no risk of causing infection. However, if the same child needed protection from polio, the nurse would ensure the Inactivated Polio Vaccine (IPV) is given instead of the live Oral Polio Vaccine (OPV).
How to Approach the Question
- First, identify the negative framing of the question. The keyword is 'NOT', which means you are looking for the exception among the options.
- Recall the classification of each vaccine listed in the options: Is it a live vaccine or an inactivated/killed/subunit vaccine?
- Categorize each option: BCG is live, OPV is live, HIB is inactivated (subunit), and Typhoid has both live (oral) and inactivated (injectable) forms.
- Analyze the options based on the question. Since HIB is always an inactivated vaccine, it is definitively 'not a live vaccine'.
- Consider the ambiguity of the 'Typhoid' option. Because a live typhoid vaccine exists (Ty21a), it cannot be the correct answer to a question asking what is not a live vaccine.
- Select HIB as the most accurate and unambiguous answer.
Concept Tested & Keywords
- Concept Tested: Classification of vaccines (Live vs. Inactivated)
- Stem keywords: live vaccine, Typhoid, HIB vaccine, OPV, BCG
- Lead-in keywords: not
- Negative lead-in flag: Question asks to identify the option that is NOT a live vaccine.
Question ID
QY_3kxqFacWn0ZuS-i4Lf9
Reference Book
E6 Parks TextBook of Preventive & Social Medicine part 1 — Subpart A (pp 26-201 of 604) p. 96-98
E6 Ghai Essential Pediatrics(pp 26-904 of 913) p. 203-205
Practise the full DSSSB Public Health Nurse - 2015
Attempt every question from this paper in a timed mock, then review the full solution for each one.
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