DSSSB 13 August 2024
Pharmacology
Easy
The antidote of benzodiazepine is:
Appeared in: DSSSB 13 August 2024
Explanation
- Flumazenil is the specific antidote for benzodiazepine overdose.
- It functions as a competitive antagonist, binding to the benzodiazepine receptor site on the GABA-A receptor complex.
- This action blocks the effects of benzodiazepines, thereby reversing sedation, respiratory depression, and other signs of overdose.
Why Other Options Were Wrong
- Option A: Neostigmine is a cholinesterase inhibitor and does not act on benzodiazepine receptors.
- Option B: Dimercaprol is a chelating agent designed to bind with heavy metals, not drugs like benzodiazepines.
- Option D: Protamine sulfate is a specific antagonist for heparin and has no effect on the central nervous system depression caused by benzodiazepines.
Related Visual
Clinical Relevance
- Nursing practice connection: This is primarily an exam-oriented knowledge point with limited direct bedside application, so retain Pharmacological antidotes for specific drug classes as background academic context rather than a clinical decision trigger.
- Knowing specific antidotes is a critical nursing competency for the emergency management of drug toxicity, helping to prevent life-threatening complications like respiratory arrest.
- Nurses must use extreme caution when administering Flumazenil to patients with a history of chronic benzodiazepine use or seizure disorders, as rapid reversal can precipitate acute and potentially fatal withdrawal seizures.
- What if? If the patient had overdosed on an opioid like morphine instead of a benzodiazepine, the correct antidote would be Naloxone, which is an opioid receptor antagonist.
How to Approach the Question
- First, identify the key drug class in the question stem, which is 'benzodiazepine'.
- The question asks for the 'antidote', which is a substance that counteracts a poison or overdose.
- Access your knowledge of pharmacology, specifically focusing on common reversal agents.
- Systematically evaluate each option: Neostigmine (for neuromuscular blockers), Dimercaprol (for heavy metals), Flumazenil (for benzodiazepines), and Protamine (for heparin).
- Select the option that is the specific antagonist for the benzodiazepine class of drugs.
Concept Tested & Keywords
- Concept Tested: Pharmacological antidotes for specific drug classes.
- Stem keywords: antidote, benzodiazepine
- Lead-in keywords: is
- Negative lead-in flag: false
Question ID
QCZ1BWPHxqeS-86ALUWSxG
Reference Book
E6 Robert Boland, Marcia L. Verduin - Kaplan and Sadock's Comprehensive Text of Psychiatry-Wolters Kluwer Health (2024) (pp 1-16525 of 16525) p. 10562-10564
E6 Kaplan Sadock's Synopsis of Psychiatry-2022 (pp 1-3768 of 3768) pp. 2117-2119, 2116-2118
Practise the full DSSSB 13 August 2024
Attempt every question from this paper in a timed mock, then review the full solution for each one.
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