Identify the correct matching about clotting factor:

Appeared in: SGPGI Nursing Officer-2023

Explanation

The correct match is Calcium – Factor IV.
Calcium ions (Factor IV) are essential inorganic cofactors required for the activation of several clotting factors in the coagulation cascade.
It facilitates the binding of vitamin K-dependent clotting factors (II, VII, IX, X) to phospholipid surfaces on platelets and endothelial cells, which is a critical step for clot formation.

Clinical Relevance

Nursing practice connection: This is primarily an exam-oriented knowledge point with limited direct bedside application, so retain Nomenclature and matching of blood clotting factors with their Roman numerals as background academic context rather than a clinical decision trigger.
Understanding clotting factors is fundamental for diagnosing and managing bleeding disorders like Hemophilia A (Factor VIII deficiency) and Hemophilia B (Factor IX deficiency).
Many anticoagulant medications target specific clotting factors. For example, warfarin inhibits the synthesis of vitamin K-dependent factors (II, VII, IX, X), while direct oral anticoagulants (DOACs) target Factor Xa or thrombin (Factor IIa).
What if? If a patient has a deficiency in Factor X (Stuart-Prower factor), both the Prothrombin Time (PT) test, which evaluates the extrinsic pathway, and the Activated Partial Thromboplastin Time (aPTT) test, which evaluates the intrinsic pathway, would be prolonged because Factor X is the start of the common pathway.

How to Approach the Question

This is a factual recall question that tests your knowledge of the standard nomenclature for blood clotting factors.
First, read the question to understand that you need to find the one correct pairing of a factor's name and its Roman numeral.
Systematically evaluate each option against your memorized list of clotting factors.
For Option A: Recall that Calcium is indeed Factor IV. This is a common and fundamental fact in coagulation.
For the other options, identify the specific mismatch: Anti-Haemophilic Factor A is VIII (not IX), Prothrombin is II (not III), and Stuart-Prower factor is X (not XI).
Confirming one option is correct and the others are definitively incorrect solidifies your answer.

Concept Tested & Keywords

Concept Tested: Nomenclature and matching of blood clotting factors with their Roman numerals.
Stem keywords: clotting factor, matching
Lead-in keywords: Identify the correct matching
Negative lead-in flag: false

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E6 Pharmacology Katzung 16e p. 953-955

E6 Physiology Essentials Sembulingam 10e Part 1 p. 137-139

E6 Harper's Illustrated Biochemistry2023 (pp 26-793 of 813) p. 666-668

Practise the full SGPGI Nursing Officer-2023

Attempt every question from this paper in a timed mock, then review the full solution for each one.