Tetracycline is used as prophylaxis for?

Appeared in: JODHPUR AIIMS SNO-2018

Explanation

Tetracycline is used as prophylaxis for close contacts of patients with cholera to reduce the shedding of Vibrio cholerae bacteria.
This intervention helps to limit the spread of the infection within a household or other close-contact settings.
While effective, Doxycycline (a related long-acting tetracycline) is often preferred now due to a simpler dosing schedule.
The use of tetracycline in cholera is confirmed in standard pharmacology texts as an adjuvant therapy that reduces stool volume and duration of diarrhea.

Option A: While a tetracycline is used, the specific drug of choice for leptospirosis prophylaxis is Doxycycline (200 mg weekly), not the short-acting tetracycline.
Option B: Post-exposure prophylaxis for brucellosis requires a combination of drugs, typically Doxycycline and Rifampin, for several weeks. Tetracycline alone is insufficient.
Option D: Tetracyclines are not the primary choice for meningitis prophylaxis. Preferred agents include Rifampin, Ciprofloxacin, or Ceftriaxone.

Clinical Relevance

Nursing practice connection: This is primarily an exam-oriented knowledge point with limited direct bedside application, so retain Chemoprophylaxis for infectious diseases as background academic context rather than a clinical decision trigger.
Nurses play a key role in public health by identifying contacts of cholera patients who may require prophylaxis and educating them on medication adherence.
Understanding the correct prophylactic agent prevents ineffective treatment and the development of antimicrobial resistance.
What if? If the patient needing cholera prophylaxis is a child under 8 years old, tetracycline would be contraindicated due to the risk of tooth discoloration and bone growth issues. An alternative like azithromycin would be considered.

How to Approach the Question

First, identify the keywords in the question: 'Tetracycline' and 'prophylaxis'. This is a factual recall question from pharmacology.
Recall the primary indications for tetracycline. Think about its spectrum of activity, which includes bacteria like Vibrio cholerae.
Evaluate each option. Consider the standard prophylactic regimens for each disease.
For Leptospirosis, recall that Doxycycline is the specific agent used.
For Brucellosis, remember that combination therapy is required.
For Meningitis, recall that drugs like Rifampin or Ciprofloxacin are first-line.

Concept Tested & Keywords

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E6 Pharmacology Katzung 16e p. 1267-1269

E6 Pharmacology KD Tripathi Essentials 9e Part 3 p. 69-71

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