UP NHM CHO 7 Sept 2022(shift-1st)
Medical & Surgical Nursing
Medium

Which of the following is NOT a cause of anaemia in Chronic Kidney Disease?

Appeared in: UP NHM CHO 7 Sept 2022(shift-1st)

Explanation

  • In Chronic Kidney Disease (CKD), the body's ability to regulate minerals like calcium and phosphate is impaired, leading to secondary hyperparathyroidism.
  • This condition is characterized by elevated levels of parathyroid hormone (PTH), not reduced levels.
  • High levels of PTH act as a uremic toxin that can suppress the bone marrow's ability to produce red blood cells and can also lead to bone marrow fibrosis.
  • Therefore, a reduced level of parathyroid hormone is not a cause of anemia in CKD; the opposite (elevated level) is a contributing factor.

Why Other Options Were Wrong

  • Option A: This is the primary and most significant cause of anemia in CKD. The kidneys are the main producers of erythropoietin (EPO), a hormone essential for stimulating red blood cell production.
  • Option B: This is a very common cause of anemia in CKD patients. Factors include poor dietary absorption, blood loss from frequent testing, and blood remaining in the dialysis machine after treatment.
  • Option D: This is a potential cause of anemia in CKD. Folate is a water-soluble vitamin that can be removed from the blood during dialysis, leading to deficiency if not adequately supplemented.

Related Visual

Visual explanation — Related Visual
Clinical Relevance
  • Nursing practice connection: Knowing Pathophysiology of anemia in Chronic Kidney Disease (CKD) helps nurses interpret findings accurately and avoid errors in routine assessment, medication administration, and patient teaching.
  • Nurses play a crucial role in managing anemia in CKD patients by administering Erythropoiesis-Stimulating Agents (ESAs) and iron supplements as prescribed.
  • Monitoring hemoglobin levels, iron studies (ferritin, transferrin saturation), and vital signs is essential to assess treatment effectiveness and prevent complications like hypertension from ESA therapy.
  • Patient education is key, focusing on dietary sources of iron and folate, adherence to medication, and recognizing symptoms of anemia like fatigue and shortness of breath.
How to Approach the Question
  • First, identify the negative keyword 'NOT' in the question stem. This means you are looking for the option that is FALSE.
  • The question asks for something that is NOT a cause of anemia in Chronic Kidney Disease (CKD).
  • Evaluate each option based on your knowledge of CKD pathophysiology.
  • Recall that the primary cause is reduced erythropoietin production by the failing kidneys.
  • Remember that iron and folate deficiencies are common due to dialysis losses and poor nutrition.
  • Consider the role of parathyroid hormone. CKD causes mineral and bone disorders, leading to high PTH (secondary hyperparathyroidism), which suppresses the bone marrow.
Concept Tested & Keywords
  • Concept Tested: Pathophysiology of anemia in Chronic Kidney Disease (CKD)
  • Stem keywords: anaemia, Chronic Kidney Disease, cause
  • Lead-in keywords: NOT
  • Negative lead-in flag: Question asks for the exception

Question ID

QFDDKx27Bv6mS6cSribuq9

Reference Book

E6 Medicine Harrison 22e Part 2 p. 297-299

E6 Medicine Harrison 22e Part 1 p. 809-811

Practise the full UP NHM CHO 7 Sept 2022(shift-1st)

Attempt every question from this paper in a timed mock, then review the full solution for each one.

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