When blood samples are collected to study inheritance patterns within families whose members have been diagnosed with schizophrenia, it is called ______.

Appeared in: UP NHM CHO 7 Sept 2022(shift-1st)

Explanation

Genetic linkage analysis is the correct term for the method described.
This technique specifically focuses on studying the co-segregation (inheritance together) of genetic markers and a disease within families or pedigrees.
The goal is to map the location of a disease-associated gene by finding a marker that is consistently inherited along with the disease.
It is a foundational method for identifying genes in disorders that show strong familial inheritance patterns, such as schizophrenia.

Why Other Options Were Wrong

Option A: Psycho-somatic analysis studies the link between psychological stress and physical symptoms, not the genetic basis of a disease.
Option C: 'Genetic blood work' is a vague, non-specific layperson's term. It does not describe a specific scientific methodology like linkage analysis.
Option D: 'Hemo-predisposition analysis' is a fabricated term with no meaning in genetics or medicine. The prefix 'hemo-' relates to blood, but the term as a whole is not valid.

Related Visual

Clinical Relevance

Nursing practice connection: Knowing Methods of Genetic Research in Psychiatry helps nurses interpret findings accurately and avoid errors in routine assessment, medication administration, and patient teaching.
Understanding genetic linkage analysis helps nurses appreciate the research behind identifying individuals and families at risk for heritable conditions like schizophrenia.
Nurses, especially in psychiatric and genetic counseling settings, can use this knowledge to educate patients and families about the genetic components of their illness and the purpose of research studies they may be invited to join.
This knowledge is crucial for interpreting family histories and recognizing patterns that may warrant a referral for genetic counseling.

How to Approach the Question

First, break down the question stem to identify the key concepts: 'blood samples,' 'inheritance patterns,' 'within families,' and 'schizophrenia.'
The crucial phrase is 'inheritance patterns within families.' This points towards a method that specifically tracks traits through a family tree (pedigree).
Evaluate the options based on this key concept.
Option A, 'Psycho-somatic analysis,' relates to the mind-body connection, not genetics. Eliminate it.
Option C, 'Genetic blood work,' is too general and not a specific scientific method. Eliminate it.
Option D, 'Hemo-predisposition analysis,' sounds technical but is not a standard term. It is likely a distractor. Eliminate it.

Concept Tested & Keywords

Concept Tested: Methods of Genetic Research in Psychiatry
Stem keywords: blood samples, inheritance patterns, families, schizophrenia
Lead-in keywords: is called
Negative lead-in flag: false

Question ID

Qplcg6TlalfSzDWHqi0gB1

Reference Book

E6 Robert Boland, Marcia L. Verduin - Kaplan and Sadock's Comprehensive Text of Psychiatry-Wolters Kluwer Health (2024) (pp 1-16525 of 16525) p. 944-946

E6 Kaplan Sadock's Synopsis of Psychiatry-2022 (pp 1-3768 of 3768) pp. 3104-3106, 3105-3107

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