The cytoplasmic hyaline inclusions of liver cells, mainly seen in alcoholic hepatitis and also occur with non-alcoholic steatohepatitis and Wilson disease is:

Appeared in: DSSSB 6 September 2024

Explanation

Mallory bodies, also known as alcoholic hyaline, are characteristic eosinophilic, irregular, rope-like hyaline inclusions found within the cytoplasm of liver cells (hepatocytes).
They are composed of tangled intermediate filaments (cytokeratins 8 and 18) and other proteins like ubiquitin, indicating cellular stress and damage to the cytoskeleton.
While classically associated with alcoholic hepatitis, they are a key feature in other liver conditions such as non-alcoholic steatohepatitis (NASH), Wilson disease, and chronic biliary tract diseases.

Option A: There is no pathological entity known as 'Keen's bodies'. This option is a distractor.
Option B: There is no pathological entity known as 'Erb's bodies'. This option is a distractor.
Option C: There is no pathological entity known as 'Kocher's bodies'. This option is a distractor.

Clinical Relevance

Nursing practice connection: Knowing Histopathological findings in liver disease helps nurses interpret findings accurately and avoid errors in routine assessment, medication administration, and patient teaching.
Identifying Mallory bodies in a liver biopsy is a key diagnostic marker for steatohepatitis (both alcoholic and non-alcoholic), indicating significant liver cell injury.
Their presence, along with hepatocyte ballooning and neutrophilic inflammation, helps pathologists grade the severity of liver disease and guides clinical management and prognosis.
What if? If the inclusions were found in the cytoplasm of neurons in the substantia nigra instead of the liver, the correct answer would be Lewy bodies, which are characteristic of Parkinson's disease.

How to Approach the Question

First, analyze the question to identify the key terms: 'cytoplasmic hyaline inclusions,' 'liver cells,' and the associated diseases ('alcoholic hepatitis,' 'NASH,' 'Wilson disease').
This is a factual recall question requiring knowledge of specific histopathological findings in liver disease.
Evaluate each option. Recognize that 'Keen,' 'Erb,' and 'Kocher' are eponyms primarily associated with clinical signs, neurology, and surgery, respectively, not liver cell inclusions.
Recall or deduce that 'Mallory bodies' is the specific term for the described inclusions in liver pathology.
Select the option that correctly names this specific pathological finding.

Concept Tested & Keywords

Concept Tested: Histopathological findings in liver disease
Stem keywords: cytoplasmic hyaline inclusions, liver cells, alcoholic hepatitis, non-alcoholic steatohepatitis, Wilson disease
Lead-in keywords: is

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E6 Pathology- ROBBINS & COTRAN PATHOLOGIC BASIS OF DISEASE 10TH Ed pp. 844-846, 74-76

E6 PATHOLOGY QUICK REVIEWBased on Harsh Mohan Textbook of PATHOLOGY p. 161-163

Practise the full DSSSB 6 September 2024

Attempt every question from this paper in a timed mock, then review the full solution for each one.