DHS Staff Nurse - 2018 (Shift-2nd)
Applied Physiology
Easy
Neuropeptide hormone, except?
Appeared in: DHS Staff Nurse - 2018 (Shift-2nd)
Explanation
- Oxytocin is classified as a neuropeptide hormone.
- It is synthesized in the cell bodies of neurons located in the supraoptic and paraventricular nuclei of the hypothalamus.
- These neurons transport Oxytocin down their axons to the posterior pituitary (neurohypophysis), from where it is released directly into the bloodstream.
- This origin in neural tissue and release from nerve endings is the defining characteristic of a neuropeptide hormone.
Why Other Options Were Wrong
- Option A: Follicle-Stimulating Hormone (FSH) is a glycoprotein hormone, not a neuropeptide. It is produced and secreted by the gonadotropic cells of the anterior pituitary, which is glandular tissue.
- Option B: Insulin is a peptide hormone, not a neuropeptide. It is synthesized and secreted by the beta cells of the islets of Langerhans in the pancreas, an endocrine gland.
- Option D: Glucagon is a peptide hormone, not a neuropeptide. It is synthesized and secreted by the alpha cells of the islets of Langerhans in the pancreas.
Related Visual
Clinical Relevance
- Nursing practice connection: This is primarily an exam-oriented knowledge point with limited direct bedside application, so retain Hormone Classification: Neuropeptides vs. Glandular Hormones as background academic context rather than a clinical decision trigger.
- Understanding hormone classification is crucial for pharmacology. For example, synthetic Oxytocin (Pitocin) is used to induce labor, while Insulin is administered to manage diabetes mellitus.
- Nurses must recognize the signs of hormonal imbalance. For instance, issues with Oxytocin can affect childbirth and lactation, while imbalances in Insulin and Glucagon lead to critical blood sugar dysregulation.
- The hypothalamic-pituitary axis is a master regulator of the endocrine system. Dysfunction here, as seen in some brain injuries or tumors, can have widespread effects on hormones like FSH and Oxytocin.
How to Approach the Question
- First, analyze the question stem: 'Neuropeptide hormone, except?'. Recognize that the word 'except' makes the question ambiguous, as it implies three options are neuropeptides and one is not.
- Next, evaluate the options based on their classification. Recall or determine the origin of each hormone: FSH (anterior pituitary), Insulin (pancreas), Oxytocin (hypothalamus/posterior pituitary), Glucagon (pancreas).
- Identify the 'odd one out'. Notice that FSH, Insulin, and Glucagon are all produced by glandular tissue, whereas Oxytocin is produced by neural tissue (neurons in the hypothalamus).
- Conclude that Oxytocin is the only neuropeptide in the list. The other three are exceptions to this category.
- Based on this, infer the most probable intent of the question was to ask 'Which of the following is a neuropeptide hormone?', which has a single correct answer.
- Select Oxytocin as the answer, understanding the flawed nature of the original question phrasing.
Concept Tested & Keywords
- Concept Tested: Hormone Classification: Neuropeptides vs. Glandular Hormones
- Stem keywords: Neuropeptide hormone, FSH, Insulin, Oxytocin, Glucagon
- Lead-in keywords: except
- Negative lead-in flag: The question uses 'except', which creates ambiguity. The likely intent is to identify the single neuropeptide from the list.
Question ID
QkmiE2t2xMy21CAbzeSJFJ
Reference Book
E6 Robert Boland, Marcia L. Verduin - Kaplan and Sadock's Comprehensive Text of Psychiatry-Wolters Kluwer Health (2024) (pp 1-16525 of 16525) pp. 486-488, 487-489
E6 Gynecology Williams p. 364-430
Practise the full DHS Staff Nurse - 2018 (Shift-2nd)
Attempt every question from this paper in a timed mock, then review the full solution for each one.
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