Chitranjjan National Cancer Institute Kolkata - 2021
Pharmacology
Easy
Name the non-stimulant drug with Norepinephrine reuptake inhibiting action used in the treatment of ADHD?
Appeared in: Chitranjjan National Cancer Institute Kolkata - 2021
Explanation
- Atomoxetine is classified as a non-stimulant medication used for treating ADHD.
- Its mechanism of action is the selective inhibition of the presynaptic norepinephrine transporter (NET), which increases the amount of norepinephrine in the synaptic cleft.
- It is a suitable alternative for patients who do not respond to, cannot tolerate, or have contraindications to stimulant medications (e.g., tic disorders, anxiety, substance abuse risk).
- Unlike stimulants, the therapeutic effect of Atomoxetine has a delayed onset, typically taking 2-4 weeks to become apparent, with full response at 6-12 weeks.
Why Other Options Were Wrong
- Option B: Dexamphetamine is a potent central nervous system (CNS) stimulant, not a non-stimulant. The question specifically asks for a non-stimulant drug.
- Option C: Methylphenidate is one of the most common CNS stimulants used for ADHD. It is not a non-stimulant medication.
- Option D: Pimozide is a typical antipsychotic medication. It is not indicated for the treatment of ADHD. Its primary use is for managing severe tics associated with Tourette's syndrome.
Related Visual
Clinical Relevance
- Nursing practice connection: Knowing Pharmacology of non-stimulant medications for ADHD helps nurses interpret findings accurately and avoid errors in routine assessment, medication administration, and patient teaching.
- Nurses must educate patients and their families that non-stimulant medications like Atomoxetine require consistent daily use for several weeks to achieve therapeutic effects, unlike the immediate effects of stimulants.
- Key nursing responsibilities include monitoring for potential side effects such as increased blood pressure and heart rate, decreased appetite, and rare but serious adverse effects like liver toxicity and suicidal ideation in children and adolescents.
- Atomoxetine is often taken on a full stomach to minimize gastrointestinal side effects like abdominal discomfort and nausea.
How to Approach the Question
- First, break down the question to identify the key criteria for the correct answer: (1) It must be a non-stimulant drug, (2) it must have a norepinephrine reuptake inhibiting action, and (3) it must be used for ADHD.
- Next, evaluate each option against the 'non-stimulant' criterion. Recall or identify that Dexamphetamine and Methylphenidate are well-known CNS stimulants, which immediately disqualifies them.
- Now, compare the remaining options, Atomoxetine and Pimozide.
- Assess Atomoxetine: It is known as a non-stimulant for ADHD that works as a selective norepinephrine reuptake inhibitor (SNRI). This matches all criteria.
- Assess Pimozide: Recall that this is an antipsychotic drug used for Tourette's syndrome, not a primary ADHD medication.
- Conclude that Atomoxetine is the only option that satisfies all three conditions stated in the question.
Concept Tested & Keywords
- Concept Tested: Pharmacology of non-stimulant medications for ADHD.
- Stem keywords: non-stimulant drug, Norepinephrine reuptake inhibiting, ADHD
- Lead-in keywords: Name
- Negative lead-in flag: false
Question ID
QHIAzvvUmxBtRU5WpbCATd
Reference Book
E6 Kaplan Sadock's Synopsis of Psychiatry-2022 (pp 1-3768 of 3768) p. 437-439
E6 Robert Boland, Marcia L. Verduin - Kaplan and Sadock's Comprehensive Text of Psychiatry-Wolters Kluwer Health (2024) (pp 1-16525 of 16525) p. 12124-12126
E6 Guide to Mental Health & PSYCHIATRIC NURSING R Sreevani— Part 2 (pp 290-564 of 579) p. 262-264
Practise the full Chitranjjan National Cancer Institute Kolkata - 2021
Attempt every question from this paper in a timed mock, then review the full solution for each one.
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