Human papilloma virus is cause of -

Appeared in: RUHS, Jaipur, PB B.Sc Nursing Entrance-2023

Explanation

Human Papillomavirus (HPV) is the primary etiological agent for nearly all cases of cervical cancer.
High-risk HPV types, specifically HPV-16 and HPV-18, are identified in approximately 70% of cervical cancer cases.
The viral oncoproteins E6 and E7 interfere with host tumor suppressor genes (p53 and RB), leading to malignant transformation of cervical cells.
While most HPV infections are transient and cleared by the immune system, persistent infection with high-risk types is the most significant risk factor for developing cervical intraepithelial neoplasia and invasive cancer.

Option A: Uterine cancer (endometrial cancer) is primarily associated with hormonal factors, such as prolonged estrogen exposure, and metabolic conditions like obesity, not HPV infection.
Option C: Peptic ulcers are primarily caused by the bacterium Helicobacter pylori or the long-term use of NSAIDs. It is not a viral-induced condition.
Option D: Hepatitis B is a liver disease caused by the Hepatitis B virus (HBV). While chronic HBV is a major cause of liver cancer, it is a distinct virus from HPV.

Clinical Relevance

Nursing practice connection: This is primarily an exam-oriented knowledge point with limited direct bedside application, so retain Etiology of Cervical Cancer as background academic context rather than a clinical decision trigger.
Understanding the link between HPV and cervical cancer is crucial for patient education on prevention through vaccination (Gardasil, Cervarix) and early detection through screening (Pap smear, HPV testing).
Nurses play a key role in advocating for and administering the HPV vaccine to eligible individuals (typically pre-teens) to prevent future cancers.
Patient counseling should emphasize that while HPV is common, most infections do not lead to cancer, but regular screening is essential to detect and treat precancerous changes.

How to Approach the Question

First, identify the key term in the question stem: 'Human papilloma virus (HPV)'.
This is a factual recall question. Access your knowledge base about common pathogens and the diseases they cause.
Evaluate each option to see which disease is directly caused by HPV.
Recall that Uterine cancer is hormonal, Peptic ulcer is bacterial (H. pylori) or drug-induced (NSAIDs), and Hepatitis B is caused by a different virus (HBV).
Conclude that Cervical cancer is the well-established malignancy caused by persistent high-risk HPV infection.

Concept Tested & Keywords

Qd096UVvoUdOzyKDAVxA3R

E6 Pathology- ROBBINS & COTRAN PATHOLOGIC BASIS OF DISEASE 10TH Ed pp. 995-997, 331-333

E6 Medicine Harrison 22e Part 1 p. 1567-1569

Practise the full RUHS, Jaipur, PB B.Sc Nursing Entrance-2023

Attempt every question from this paper in a timed mock, then review the full solution for each one.