Dose-related adverse drug reaction is called:

Appeared in: RIMS Nursing Officer - 2022

Explanation

Augmented (Type A) reactions are adverse effects that are directly related to the dose of the drug administered.
These reactions are predictable based on the known pharmacological properties of the drug. For example, a higher dose of an antihypertensive drug is expected to cause a greater drop in blood pressure, potentially leading to hypotension.
They are the most common type of ADR and can often be managed by adjusting the dosage rather than stopping the drug completely.
Examples include bleeding with anticoagulants like warfarin, drowsiness with sedatives, or hypoglycemia with insulin.

Option A: Bizarre (Type B) reactions are, by definition, not related to the dose. They are unpredictable and often stem from a patient's unique immunological or genetic makeup.
Option C: End of Use (Type E) reactions are not caused by the dose being administered but are withdrawal effects that occur upon cessation of the drug.
Option D: Failure (Type F) refers to a lack of the drug's intended therapeutic effect, not an adverse reaction caused by the dose.

Clinical Relevance

Nursing practice connection: Knowing Classification of Adverse Drug Reactions (ADRs) helps nurses interpret findings accurately and avoid errors in routine assessment, medication administration, and patient teaching.
Nurses play a crucial role in identifying and managing dose-related ADRs by adhering to the 'five rights' of medication administration and carefully monitoring patients after giving a drug.
Patient education is key. Nurses must teach patients to recognize and report early signs of dose-related side effects (e.g., excessive drowsiness with opioids, increased bruising with warfarin).
Accurate documentation and reporting of all suspected ADRs through systems like the Pharmacovigilance Programme of India (PvPI) is a vital professional responsibility for nurses to ensure patient safety and improve drug knowledge.

How to Approach the Question

First, identify the core concept in the question stem, which is 'dose-related adverse drug reaction'.
Recall the standard pharmacological classification of Adverse Drug Reactions (ADRs), often remembered by the mnemonic ABCDEF.
Match the term 'dose-related' to the correct category in the classification.
Type A (Augmented) reactions are defined as being dose-related and predictable.
Evaluate the given options: 'Bizarre' (Type B) is non-dose-related, 'End of Use' (Type E) is about withdrawal, and 'Failure' (Type F) is about lack of efficacy. Therefore, 'Augmented' is the correct match.

Concept Tested & Keywords

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E6 Medicine Davidson Principles Practice 24e p. 42-44

E6 Pharmacology KD Tripathi Essentials 9e Part 1 p. 118-120

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