Q2. What is the mechanism of action of Resmetirom?

Appeared in: INI-CET EXAM -2026

Explanation

Resmetirom is a selective agonist for the Thyroid Hormone Receptor-β (THR-β).
THR-β is predominantly expressed in the liver.
Activation of THR-β by Resmetirom increases hepatic fat metabolism, thereby reducing the amount of fat in the liver.
This action helps in resolving non-alcoholic steatohepatitis (NASH) and improving liver fibrosis.

Option A: This describes the mechanism of Ezetimibe, a cholesterol-lowering medication.
Option B: This is the mechanism of action for thiazolidinediones (e.g., Pioglitazone), which are used to treat type 2 diabetes.
Option C: This mechanism, while relevant to liver fat metabolism, is not the primary action of Resmetirom. It is a target for other investigational drugs for NASH.

Clinical Relevance

Nursing practice connection: This is primarily an exam-oriented knowledge point with limited direct bedside application, so retain Mechanism of action of Resmetirom as background academic context rather than a clinical decision trigger.
Resmetirom is the first drug approved for non-alcoholic steatohepatitis (NASH) with moderate to advanced liver fibrosis, representing a major breakthrough in hepatology.
Nurses will be responsible for educating patients about this new medication, its purpose, administration, and potential side effects.
Monitoring liver function tests (LFTs) is a key nursing intervention for patients on Resmetirom to assess treatment efficacy and monitor for any adverse hepatic effects.

How to Approach the Question

This is a factual recall question about pharmacology.
First, identify the drug named in the question: Resmetirom.
Second, recall or determine the drug class and its specific mechanism of action. Resmetirom is a novel drug, so this may require specific knowledge.
Third, evaluate each option against the known mechanism. Option A (NPC1L1) is for Ezetimibe. Option B (PPAR-γ) is for thiazolidinediones. Option C (Acetyl-CoA carboxylase) is for other investigational drugs.
Finally, select the option that accurately describes the drug's action. Resmetirom is known to be a THR-β agonist, making option D the correct choice.

Concept Tested & Keywords

QfMMREo22hcYUbauSkPXWA

E6 Pharmacology Katzung 16e p. 994-996

E6 Textbook of Biochemistry for medical StudentsDM Vasudevan Part 1 (pp 26-370 of 370) p. 249-251

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Attempt every question from this paper in a timed mock, then review the full solution for each one.