Normal glomerular filtration (GFR) rate is?

Appeared in: ISRO- 2016

Explanation

The Glomerular Filtration Rate (GFR) is the standard measure for assessing kidney excretory function.
In a healthy average-sized adult, the normal GFR is approximately 125 ml per minute.
This rate corresponds to the filtration of about 180 liters of plasma per day through the glomeruli.
GFR is determined by the balance of hydrostatic and colloid osmotic forces across the glomerular capillary membrane.

Option A: A GFR of 100 ml/min is at the lower end of the normal range and, if persistently lower, could suggest early stages of kidney function decline, but it is not the standard average value.
Option C: A GFR of 150 ml/min is significantly higher than the average normal rate. While temporary increases can occur, this is not a typical resting value.
Option D: A GFR of 175 ml/min is well above the normal physiological range for an adult and is not considered a normal value.

Clinical Relevance

Nursing practice connection: This is primarily an exam-oriented knowledge point with limited direct bedside application, so retain Normal Glomerular Filtration Rate (GFR) as background academic context rather than a clinical decision trigger.
GFR is a critical parameter nurses monitor to assess kidney function and stage Chronic Kidney Disease (CKD).
Many drug dosages, especially those for antibiotics, anticoagulants, and chemotherapy, must be adjusted based on the patient's GFR to prevent toxicity.
A declining GFR alerts the healthcare team to potential kidney damage from conditions like diabetes, hypertension, or nephrotoxic medications.

How to Approach the Question

First, identify the core concept of the question, which is the 'normal glomerular filtration (GFR) rate'.
This is a factual recall question based on fundamental physiological values.
Recall the standard textbook value for GFR in a healthy adult.
Compare the recalled value (approximately 125 ml/min) with the given options.
Select the option that matches the standard physiological value.

Concept Tested & Keywords

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E6 Physiology Guyton 4SAE Part 2B p. 19-21

E6 Pathology-Textbook of PATHOLOGYHarsh Mohan Part 3 (515-969) p. 147-149

Practise the full ISRO- 2016

Attempt every question from this paper in a timed mock, then review the full solution for each one.