INI-CET EXAM -2025
Pharmacology
Medium
All of the following statements regarding Dronabinol are correct except?
Appeared in: INI-CET EXAM -2025
Explanation
- The statement that Dronabinol is excreted unchanged in the urine is incorrect.
- Dronabinol is a highly lipophilic drug that undergoes extensive first-pass metabolism in the liver by the cytochrome P450 enzyme system.
- It is converted into active and inactive metabolites.
- These metabolites, not the unchanged drug, are then excreted from the body, primarily via the feces and to a lesser extent in the urine.
Why Other Options Were Wrong
- Option A: This is a correct statement. While not a primary FDA-approved indication for Dronabinol itself, cannabinoids as a drug class are recognized for their analgesic properties and are used in the management of chronic and neuropathic pain.
- Option C: This is a correct statement. Dronabinol is a synthetic form of delta-9-tetrahydrocannabinol (THC), the primary psychoactive component of cannabis. Its therapeutic effects are mediated by acting as an agonist at cannabinoid receptors, primarily the CB₁ receptors found in the central nervous system.
- Option D: This is a correct statement. Dronabinol is FDA-approved for the treatment of anorexia associated with weight loss in patients with Acquired Immunodeficiency Syndrome (AIDS). It acts as an appetite stimulant in this population.
Related Visual
- Visual 1: Table - A summary table of Dronabinol's pharmacokinetics (Absorption, Distribution, Metabolism, Excretion) to clearly show it is metabolized and not excreted unchanged.
- Visual 2: Diagram - A simple diagram of the endocannabinoid system showing the CB1 and CB2 receptors to illustrate the drug's mechanism of action.
Clinical Relevance
- Nursing practice connection: This is primarily an exam-oriented knowledge point with limited direct bedside application, so retain Pharmacology of Dronabinol as background academic context rather than a clinical decision trigger.
- Nurses administering Dronabinol must monitor for common side effects, including CNS effects like drowsiness, dizziness, confusion, and euphoria. Patients should be cautioned against driving or operating heavy machinery.
- Cardiovascular effects such as tachycardia and hypotension can occur, requiring monitoring of heart rate and blood pressure, especially in patients with pre-existing heart conditions.
- Patient education is crucial. The nurse should explain that the drug is intended to help with appetite or nausea and discuss potential psychoactive effects.
How to Approach the Question
- First, identify that the question uses the word 'except'. This means you are looking for the statement that is FALSE.
- Read the stem of the question to identify the core subject: the drug Dronabinol.
- Evaluate each option independently based on your knowledge of pharmacology.
- Option A: Recall the uses of cannabinoids. Are they used for pain? Yes.
- Option B: Consider the pharmacokinetics. Are drugs, especially lipophilic ones, often excreted unchanged? No, they are usually metabolized first. This should be a red flag.
- Option C: Think about the drug class. Dronabinol is a cannabinoid. How do they work? By acting on cannabinoid receptors.
Concept Tested & Keywords
- Concept Tested: Pharmacology of Dronabinol
- Stem keywords: Dronabinol, pharmacology
- Lead-in keywords: except
- Negative lead-in flag: This is a negative-lead-in question, asking you to identify the INCORRECT statement.
Question ID
QsiooyvD66OnnZI70oWb6c
Practise the full INI-CET EXAM -2025
Attempt every question from this paper in a timed mock, then review the full solution for each one.
More General Pharmacology Questions
- Patient with DVT is advised low molecular heparin. At which site nurse will administer this?
- The unpredicted effect of medication in which a client overacts or underacts to a medication is termed:
- A Nursing officer is working in eye ward. A doctor ordered for a specific eye disease an ointment and an eye drops, a prudent nursing officer should…
- You are administering medications to a patient through an intravenous (IV) line. Suddenly, you notice that the IV site is becoming red, swollen, and…
- A physician orders a medication to be administered to a patient in a dose of 200mg twice daily (BD). The pharmacy provides tablets of the medication,…
- Desired dose of Morphine for a patient is 0.4 mg. Dose available is 1 mg/mL. The correct formulation for this patient is:
- What is the precautionary step to be taken before administering an antiserum (or) antitoxin?
- Preferred route of tranexamic acid drug administration is?
- Most common adverse effects of inactivated polio vaccine (IPV)?
- Expected outcome of dopamine is?
More INI-CET EXAM -2025 Questions
- The highlighted structure in the provided image articulates with which bone?& x20;
- Through which of the following foramina does the nerve supplying the muscles of mastication pass?& x20;
- In the given image, which region is correctly paired with its corresponding brain structure? • Middle cerebellar peduncle • Fasciculus cuneatus • Sup…
- Which of the following muscles is NOT typically associated with dysphagia or dysarthria?
- A muscle of mastication involved in opening the mouth exhibits the following characteristics. Identify the incorrect statement about it:
- In the illustrated image, which of the following structures is NOT associated with the area marked by the arrow?& x20;
- Match the following embryonic aortic arches with their respective adult derivatives: A. 1st Arch 1. Maxillary artery& x20; B. 2nd Arch 2. Common caro…
- Which of the following histology image is not an endocrine structure?& x20;
- Marked structure separates which of the following:
- Which of the following bones of the skull gives passage to a nerve arising from the brain & x20;